Circum-planetary discs as bottlenecks for gas accretion onto giant planets

With hundreds of exoplanets detected, it is necessary to revisit giant planets accretion models to explain their mass distribution. In particular, formation of sub-jovian planets remains unclear, given the short timescale for the runaway accretion of massive atmospheres. However, gas needs to pass through a circum-planetary disc. If the latter has a low viscosity (as expected if planets form in "dead zones"), it might act as a bottleneck for gas accretion. We investigate what the minimum accretion rate is for a planet under the limit assumption that the circum-planetary disc is totally inviscid, and the transport of angular momentum occurs solely because of the gravitational perturbations from the star. To estimate the accretion rate, we present a steady-state model of an inviscid circum-planetary disc, with vertical gas inflow and external torque from the star. Hydrodynamical simulations of a circum-planetary disc were conducted in 2D, in a planetocentric frame, with the star as an external perturber in order to measure the torque exerted by the star on the disc. The disc shows a two-armed spiral wave caused by stellar tides, propagating all the way in from the outer edge of the disc towards the planet. The stellar torque is small and corresponds to a doubling time for a Jupiter mass planet of the order of 5 Myrs. Given the limit assumptions, this is clearly a lower bound of the real accretion rate. This result shows that gas accretion onto a giant planet can be regulated by circum-planetary discs. This suggests that the diversity of masses of extra-solar planets may be the result of different viscosities in these discs.Comment: Accepted for publication in Astronomy and Astrophysics. 7 pages, 2 figure

Optimization of star research algorithm for esmo star tracker

This paper explains in detail the design and the development of a software research star algorithm, embedded on a star tracker, by the ISAE/SUPAERO team. This research algorithm is inspired by musical techniques. This work will be carried out as part of the ESMO (European Student Moon Orbiter) project by different teams of students and professors from ISAE/SUPAERO (Institut Supe ́rieur de l’Ae ́ronautique et de l’Espace). Till today, the system engineering studies have been completed and the work that will be presented will concern the algorithmic and the embedded software development. The physical architecture of the sensor relies on APS 750 developed by the CIMI laboratory of ISAE/SUPAERO. First, a star research algorithm based on the image acquired in lost-in-space mode (one of the star tracker opera- tional modes) will be presented; it is inspired by techniques of musical recognition with the help of the correlation of digital signature (hash) with those stored in databases. The musical recognition principle is based on finger- printing, i.e. the extraction of points of interest in the studied signal. In the musical context, the signal spectrogram is used to identify these points. Applying this technique in image processing domain requires an equivalent tool to spectrogram. Those points of interest create a hash and are used to efficiently search within the database pre- viously sorted in order to be compared. The main goals of this research algorithm are to minimise the number of steps in the computations in order to deliver information at a higher frequency and to increase the computation robustness against the different possible disturbances

Enseignement de l’ingénierie système : retour sur la conception d’un senseur stellaire pour ESEO et ESMO

Cet article présente la conception et le développement du logiciel embarqué d’un senseur stellaire, dans le cadre des projets étudiants de l’ESA (Agence Spatiale Européenne), tels ESEO (European Student Earth Orbiter) et ESMO (European Student Moon Orbiter). Ces projets sont menés au sein de l’ISAE (Institut Supérieur de l’Aéronautique et de l’Espace) par des élèves du cycle ingénieur de la formation SUPAERO, avec le soutien des équipes d’enseignants-chercheurs et des laboratoires de l’institut. Un senseur stellaire est un système complexe, composé d’une partie électronique, constituée de lentilles optiques, d’un déflecteur de lumière, d’un capteur, d’un micro-ordinateur et d’une partie logicielle comprenant les algorithmes de calcul et la base des données persistantes. Cet article se concentre sur l’application de la démarche d’ingénierie système, depuis le processus d’ingénierie du besoin jusqu’au processus d’architecture, permettant d’aboutir à une description physique de senseur stellaire

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments.

International audienceSHANK genes code for scaffold proteins located at the post-synaptic density of glutamatergic synapses. In neurons, SHANK2 and SHANK3 have a positive effect on the induction and maturation of dendritic spines, whereas SHANK1 induces the enlargement of spine heads. Mutations in SHANK genes have been associated with autism spectrum disorders (ASD), but their prevalence and clinical relevance remain to be determined. Here, we performed a new screen and a meta-analysis of SHANK copy-number and coding-sequence variants in ASD. Copy-number variants were analyzed in 5,657 patients and 19,163 controls, coding-sequence variants were ascertained in 760 to 2,147 patients and 492 to 1,090 controls (depending on the gene), and, individuals carrying de novo or truncating SHANK mutations underwent an extensive clinical investigation. Copy-number variants and truncating mutations in SHANK genes were present in ∼1% of patients with ASD: mutations in SHANK1 were rare (0.04%) and present in males with normal IQ and autism; mutations in SHANK2 were present in 0.17% of patients with ASD and mild intellectual disability; mutations in SHANK3 were present in 0.69% of patients with ASD and up to 2.12% of the cases with moderate to profound intellectual disability. In summary, mutations of the SHANK genes were detected in the whole spectrum of autism with a gradient of severity in cognitive impairment. Given the rare frequency of SHANK1 and SHANK2 deleterious mutations, the clinical relevance of these genes remains to be ascertained. In contrast, the frequency and the penetrance of SHANK3 mutations in individuals with ASD and intellectual disability-more than 1 in 50-warrant its consideration for mutation screening in clinical practice

On the spontaneous stochastic dynamics of a single gene: complexity of the molecular interplay at the promoter

International audienceBACKGROUND: Gene promoters can be in various epigenetic states and undergo interactions with many molecules in a highly transient, probabilistic and combinatorial way, resulting in a complex global dynamics as observed experimentally. However, models of stochastic gene expression commonly consider promoter activity as a two-state on/off system. We consider here a model of single-gene stochastic expression that can represent arbitrary prokaryotic or eukaryotic promoters, based on the combinatorial interplay between molecules and epigenetic factors, including energy-dependent remodeling and enzymatic activities. RESULTS: We show that, considering the mere molecular interplay at the promoter, a single-gene can demonstrate an elaborate spontaneous stochastic activity (eg. multi-periodic multi-relaxation dynamics), similar to what is known to occur at the gene-network level. Characterizing this generic model with indicators of dynamic and steady-state properties (including power spectra and distributions), we reveal the potential activity of any promoter and its influence on gene expression. In particular, we can reproduce, based on biologically relevant mechanisms, the strongly periodic patterns of promoter occupancy by transcription factors (TF) and chromatin remodeling as observed experimentally on eukaryotic promoters. Moreover, we link several of its characteristics to properties of the underlying biochemical system. The model can also be used to identify behaviors of interest (eg. stochasticity induced by high TF concentration) on minimal systems and to test their relevance in larger and more realistic systems. We finally show that TF concentrations can regulate many aspects of the stochastic activity with a considerable flexibility and complexity. CONCLUSIONS: This tight promoter-mediated control of stochasticity may constitute a powerful asset for the cell. Remarkably, a strongly periodic activity that demonstrates a complex TF concentration-dependent control is obtained when molecular interactions have typical characteristics observed on eukaryotic promoters (high mobility, functional redundancy, many alternate states/pathways). We also show that this regime results in a direct and indirect energetic cost. Finally, this model can constitute a framework for unifying various experimental approaches. Collectively, our results show that a gene - the basic building block of complex regulatory networks - can itself demonstrate a significantly complex behavior

Numerical simulations of biofouling effects on the tidal turbine hydrodynamic

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Hydrodynamic consequences of biofouling organisms on marine energy converters

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